I have owned this DR650SE now for 3 months. In that time, I have put on about 400 miles. I ride almost entirely on the streets, as off-roading holds little interest for me (but, would like to try it sometime though). For the most part, this bike (my 6th bike) has met my expectations, and has exceeded in some areas.
For a 652cc single cylinder (thumper), this bike has a lot of low end torque, and a decent high end. It is among the most stable bikes I have ever owned, as the tall, knobby wheels really hold the ground well. The bike corners well, and with its light weight, it is very nimble. The gauges are easy to read, and everything seems quite accessible, especially for maintenance (which is very easy to do, mind you).
The main con with this bike, as well as this being the case with many dual sports, is the exceptionally uncomfortable stock seat. I mean, I think Suzuki purposely makes this thing as rock hard as possible! I would have given the comfort level a one or two star, but I have added a Stearns ATV seat pad, which has DRAMATICALLY improved the comfort level. In fact, I can now ride quite comfortably for over an hour without having discomfort (before, my rear end was in unbelievable pain after 10-15 minutes).
All in all, a nice bike, great looking, durable plastics, very nimble and stable, great low end torque, and I am sure it would be fun for off-roading (however, I would think this 350lb bike would be a bit heavy for that). Plus, I get 52-55mpg on a constant basis! I highly recommend the bike; just be sure to do something about the seat!